InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NMT2

Summary

InnateDB Gene

IDBG-57000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMT2

Gene Name

N-myristoyltransferase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000152465

Encoded Proteins

IDBP-57002

N-myristoyltransferase 2

IDBP-57004

N-myristoyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. [provided by RefSeq, Jul 2008]
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein\'s N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77%% and 96%% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:15102584-15168693

Strand

Reverse strand

Band

p13

Transcripts

ENST00000378165	ENSP00000367407
ENST00000378150	ENSP00000367392
ENST00000466201
ENST00000486786
ENST00000478580

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity

Biological Process

GO:0006499	N-terminal protein myristoylation
GO:0007603	phototransduction, visible light
GO:0009249	protein lipoylation
GO:0016032	viral process
GO:0016056	rhodopsin mediated signaling pathway
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0075733	intracellular transport of virus