Version 5.4
Homo sapiens Gene: SETD1B
Summary
InnateDB Gene IDBG-62002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SETD1B
Gene Name SET domain containing 1B
Synonyms KMT2G; Set1B
Species Homo sapiens
Ensembl Gene ENSG00000139718
Encoded Proteins
IDBP-62004
SET domain containing 1B
IDBP-586552
SET domain containing 1B
IDBP-813610
SET domain containing 1B
IDBP-813615
SET domain containing 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:121804180-121832584
Strand Forward strand
Band q24.31
Transcripts
ENST00000267197 ENSP00000267197
ENST00000542440 ENSP00000442924
ENST00000604567 ENSP00000474253
ENST00000619791 ENSP00000481531
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0016607 nuclear speck
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038384
View Gene Order
ENSBTAG00000004172
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q9UPS6
TrEMBL
UniProt Splice Variant
Entrez Gene 23067
UniGene Hs.507122 Hs.612133
RefSeq NM_015048 XM_005253858 XM_006719295 XM_006719296
HUGO HGNC:29187
OMIM 611055
CCDS CCDS53838
HPRD
IMGT
EMBL AB028999 AC079360 AC084018 JF813787
GenPept AEG67286 BAA83028
RNA Seq Atlas 23067

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca