Version 5.4
Bos taurus Gene: PBX1
Summary
InnateDB Gene IDBG-629771.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PBX1
Gene Name pre-B-cell leukemia transcription factor 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013801
Encoded Proteins
IDBP-681188
pre-B-cell leukemia homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185630:
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:4228463-4527283
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018349 ENSBTAP00000018349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001655 urogenital system development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0030278 regulation of ossification
GO:0030325 adrenal gland development
GO:0030326 embryonic limb morphogenesis
GO:0035162 embryonic hemopoiesis
GO:0042127 regulation of cell proliferation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048568 embryonic organ development
GO:0048706 embryonic skeletal system development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000185630
View Gene Order
ENSMUSG00000052534
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_216222
Transcriptional regulation of pluripotent stem cells pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL F1MJ02
UniProt Splice Variant
Entrez Gene 540688
UniGene Bt.78230
RefSeq NM_001192768 XM_005203438
HUGO HGNC:8632
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006829 DAAA02006830 DAAA02006831 DAAA02006832 DAAA02006833 DAAA02006834 DAAA02006835
GenPept
RNA Seq Atlas 540688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca