InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DDR1

Summary

InnateDB Gene

IDBG-634478.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDR1

Gene Name

epithelial discoidin domain-containing receptor 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010682

Encoded Proteins

IDBP-686285

discoidin domain receptor family, member 1

IDBP-686286

discoidin domain receptor family, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204580:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:27975619-27989666

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014143	ENSBTAP00000014143
ENSBTAT00000046062	ENSBTAP00000043390

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0038062	protein tyrosine kinase collagen receptor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001952	regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007566	embryo implantation
GO:0008285	negative regulation of cell proliferation
GO:0010715	regulation of extracellular matrix disassembly
GO:0014909	smooth muscle cell migration
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0043583	ear development
GO:0044319	wound healing, spreading of cells
GO:0046777	protein autophosphorylation
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060749	mammary gland alveolus development
GO:0061302	smooth muscle cell-matrix adhesion

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000204580

View Gene Order

ENSMUSG00000003534

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118779

Extracellular matrix organization pathway

REACT_163874

Non-integrin membrane-ECM interactions pathway

REACT_206066

Extracellular matrix organization pathway

REACT_196607

Non-integrin membrane-ECM interactions pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas