Version 5.4
Bos taurus Gene: SLC22A1
Summary
InnateDB Gene IDBG-635520.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A1
Gene Name Solute carrier family 22 member 1
Synonyms OCT1
Species Bos taurus
Ensembl Gene ENSBTAG00000008540
Encoded Proteins
IDBP-687360
Solute carrier family 22 member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175003:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:97750746-97787561
Strand Forward strand
Band
Transcripts
ENSBTAT00000004059 ENSBTAP00000004059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0015075 ion transmembrane transporter activity
GO:0015101 organic cation transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000175003
View Gene Order
ENSMUSG00000023829
View Gene Order
Pathways
NETPATH
REACTOME
REACT_210927
Organic cation/anion/zwitterion transport pathway
REACT_222460
SLC-mediated transmembrane transport pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_214326
Organic cation transport pathway
REACT_217054
Abacavir transport and metabolism pathway
REACT_219139
Metabolism pathway
REACT_202611
Abacavir transmembrane transport pathway
REACT_212003
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22357
Organic cation transport pathway
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_120801
Abacavir transmembrane transport pathway
REACT_15418
Norepinephrine Neurotransmitter Release Cycle pathway
REACT_13583
Neurotransmitter Clearance In The Synaptic Cleft pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_22345
Organic cation/anion/zwitterion transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_121189
Abacavir transport and metabolism pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_188937
Metabolism pathway
REACT_196556
Abacavir transport and metabolism pathway
REACT_196555
Abacavir transmembrane transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_198609
Organic cation/anion/zwitterion transport pathway
REACT_198610
Organic cation transport pathway
KEGG
hsa04976
Bile secretion pathway
mmu04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.21579
RefSeq NM_001101098
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca