InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC22A1

Summary

InnateDB Gene

IDBG-98656.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A1

Gene Name

solute carrier family 22 (organic cation transporter), member 1

Synonyms

HOCT1; OCT1; oct1_cds

Species

Homo sapiens

Ensembl Gene

ENSG00000175003

Encoded Proteins

IDBP-98658

solute carrier family 22 (organic cation transporter), member 1

IDBP-98660

solute carrier family 22 (organic cation transporter), member 1

IDBP-388155

solute carrier family 22 (organic cation transporter), member 1

IDBP-587781

solute carrier family 22 (organic cation transporter), member 1

IDBP-601498

solute carrier family 22 (organic cation transporter), member 1

IDBP-591492

solute carrier family 22 (organic cation transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:160121789-160158718

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000366963	ENSP00000355930
ENST00000324965	ENSP00000318103
ENST00000457470	ENSP00000409557
ENST00000460902	ENSP00000439274
ENST00000478607
ENST00000539263	ENSP00000443245
ENST00000540443	ENSP00000440105

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005277	acetylcholine transmembrane transporter activity
GO:0005329	dopamine transmembrane transporter activity
GO:0005333	norepinephrine transmembrane transporter activity
GO:0005515	protein binding
GO:0008504	monoamine transmembrane transporter activity
GO:0008513	secondary active organic cation transmembrane transporter activity
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006812	cation transport
GO:0006836	neurotransmitter transport
GO:0006855	drug transmembrane transport
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0015874	norepinephrine transport
GO:0034220	ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0048241	epinephrine transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:1901374	acetate ester transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane