Version 5.4
Bos taurus Gene: MADD
Summary
InnateDB Gene IDBG-637361.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MADD
Gene Name MAP kinase-activating death domain protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021700
Encoded Proteins
IDBP-689370
MAP-kinase activating death domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110514:
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78346046-78382745
Strand Forward strand
Band
Transcripts
ENSBTAT00000028927 ENSBTAP00000028927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
GO:0042981 regulation of apoptotic process
GO:0051726 regulation of cell cycle
GO:0097194 execution phase of apoptosis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000110514
View Gene Order
ENSMUSG00000040687
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
tnfpathway
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL E1BK67
UniProt Splice Variant
Entrez Gene 534306
UniGene Bt.16641
RefSeq NM_001193078 XM_005216465 XM_005216466 XM_005216467 XM_005216468
HUGO HGNC:6766
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02041602
GenPept
RNA Seq Atlas 534306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca