InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTSA

Summary

InnateDB Gene

IDBG-78417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSA

Gene Name

cathepsin A

Synonyms

GLB2; GSL; NGBE; PPCA; PPGB

Species

Homo sapiens

Ensembl Gene

ENSG00000064601

Encoded Proteins

IDBP-78419

cathepsin A

IDBP-78421

cathepsin A

IDBP-78427

cathepsin A

IDBP-78429

cathepsin A

IDBP-376780

cathepsin A

IDBP-810341

cathepsin A

IDBP-810366

cathepsin A

IDBP-810372

cathepsin A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:45890144-45898820

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000372484	ENSP00000361562
ENST00000354880	ENSP00000346952
ENST00000191018	ENSP00000191018
ENST00000372459	ENSP00000361537
ENST00000419493	ENSP00000408533
ENST00000485627
ENST00000493522
ENST00000480961
ENST00000484855
ENST00000606788	ENSP00000476235
ENST00000606394	ENSP00000475827
ENST00000607841
ENST00000606066
ENST00000607814
ENST00000607212
ENST00000607482	ENSP00000475524
ENST00000606782
ENST00000607187
ENST00000606000

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004185	serine-type carboxypeptidase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity

Biological Process

GO:0006508	proteolysis
GO:0006665	sphingolipid metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0006886	intracellular protein transport
GO:0043085	positive regulation of catalytic activity
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome