InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MBD2

Summary

InnateDB Gene

IDBG-644736.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBD2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000037457

Encoded Proteins

IDBP-697398

methyl-CpG binding domain protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134046:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:54044363-54093578

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000053498

ENSBTAP00000048789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0019904	protein domain specific binding
GO:0031492	nucleosomal DNA binding
GO:0035197	siRNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0030177	positive regulation of Wnt signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042711	maternal behavior
GO:0043044	ATP-dependent chromatin remodeling
GO:0043623	cellular protein complex assembly

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043234	protein complex