InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KCNQ1

Summary

InnateDB Gene

IDBG-645190.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNQ1

Gene Name

potassium voltage-gated channel subfamily KQT member 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010986

Encoded Proteins

IDBP-697878

potassium voltage-gated channel, KQT-like subfamily, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000053918:
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:49676546-49689396

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014583

ENSBTAP00000014583

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008157	protein phosphatase 1 binding
GO:0034236	protein kinase A catalytic subunit binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0044325	ion channel binding
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO:0097110	scaffold protein binding
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Biological Process

GO:0006349	regulation of gene expression by genetic imprinting
GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0016458	gene silencing
GO:0035690	cellular response to drug
GO:0055085	transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0060306	regulation of membrane repolarization
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
GO:0071320	cellular response to cAMP
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport
GO:0072358	cardiovascular system development
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086011	membrane repolarization during action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901381	positive regulation of potassium ion transmembrane transport

Cellular Component

GO:0005764	lysosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane