InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GR-A

Summary

InnateDB Gene

IDBG-646140.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GR-A

Gene Name

glucocorticoid receptor

Synonyms

GR-A

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019472

Encoded Proteins

IDBP-698914

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21750107

[Homo sapiens] The Glucocorticoid receptor, NR3C1, exerts anti-inflammatory action in part by antagonizing pro-inflammatory transcription factors such as RELA of the NFkB complex.

PMID 21940629

[Homo sapiens] NR3C1, the glucocorticoid receptor, is necessary for glucocorticoid-mediated induction of NLRP3 and the subsequent formation of inflammasomes, demonstrating a novel role for glucocorticoids in sensitizing the initial inflammatory response by the innate immune system. (Demonstrated in mice)

PMID 21750107

[Mus musculus] The Glucocorticoid receptor, Nr3c1 exerts anti-inflammatory action in part by antagonizing pro-inflammatory transcription factors such as Rela of the NFkB complex. (Demonstrated in human)

PMID 21940629

[Mus musculus] Nr3c1, the glucocorticoid receptor, is necessary for glucocorticoid-mediated induction of Nlrp3 and the subsequent formation of inflammasomes, demonstrating a novel role for glucocorticoids in sensitizing the initial inflammatory response by the innate immune system.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113580:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:56235966-56350171

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025941

ENSBTAP00000025941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 175 interaction(s) predicted by orthology.

Predicted by orthology
Total	175 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004883	glucocorticoid receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006111	regulation of gluconeogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008211	glucocorticoid metabolic process
GO:0030325	adrenal gland development
GO:0031946	regulation of glucocorticoid biosynthetic process
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0043402	glucocorticoid mediated signaling pathway
GO:0043525	positive regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060603	mammary gland duct morphogenesis
GO:1900170	negative regulation of glucocorticoid mediated signaling pathway