Version 5.4
Homo sapiens Gene: SLC29A4
Summary
InnateDB Gene IDBG-7459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC29A4
Gene Name solute carrier family 29 (nucleoside transporters), member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164638
Encoded Proteins
IDBP-7461
solute carrier family 29 (nucleoside transporters), member 4
IDBP-236587
solute carrier family 29 (nucleoside transporters), member 4
IDBP-292611
solute carrier family 29 (nucleoside transporters), member 4
IDBP-362502
solute carrier family 29 (nucleoside transporters), member 4
IDBP-362534
solute carrier family 29 (nucleoside transporters), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:5274369-5306870
Strand Forward strand
Band p22.1
Transcripts
ENST00000297195 ENSP00000297195
ENST00000396872 ENSP00000380081
ENST00000406453 ENSP00000385845
ENST00000434816 ENSP00000406803
ENST00000444741 ENSP00000413271
ENST00000439491
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005337 nucleoside transmembrane transporter activity
GO:0008504 monoamine transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0015844 monoamine transport
GO:0055085 transmembrane transport
GO:1901642 nucleoside transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050822
View Gene Order
ENSBTAG00000007772
Not yet available
Pathways
NETPATH
REACTOME
REACT_1206
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.4302
RefSeq NM_001040661 NM_001300847 NM_153247 XM_005249657 XM_005249658 XM_006715667 XM_006715668
HUGO
OMIM
CCDS CCDS5340 CCDS75561
HPRD 15362
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca