Version 5.4
Homo sapiens Gene: NONO
Summary
InnateDB Gene IDBG-75619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NONO
Gene Name non-POU domain containing, octamer-binding
Synonyms NMT55; NRB54; P54; P54NRB; PPP1R114
Species Homo sapiens
Ensembl Gene ENSG00000147140
Encoded Proteins
IDBP-75621
non-POU domain containing, octamer-binding
IDBP-75623
non-POU domain containing, octamer-binding
IDBP-75625
non-POU domain containing, octamer-binding
IDBP-375311
non-POU domain containing, octamer-binding
IDBP-375314
non-POU domain containing, octamer-binding
IDBP-375317
non-POU domain containing, octamer-binding
IDBP-375321
non-POU domain containing, octamer-binding
IDBP-375323
non-POU domain containing, octamer-binding
IDBP-600810
non-POU domain containing, octamer-binding
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:71283192-71301168
Strand Forward strand
Band q13.1
Transcripts
ENST00000276079 ENSP00000276079
ENST00000373856 ENSP00000362963
ENST00000373841 ENSP00000362947
ENST00000420903 ENSP00000410299
ENST00000413858 ENSP00000413350
ENST00000450092 ENSP00000415777
ENST00000454976 ENSP00000406673
ENST00000418921 ENSP00000409773
ENST00000474431
ENST00000472185
ENST00000486613
ENST00000471419
ENST00000490044
ENST00000473525
ENST00000535149 ENSP00000441364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 157 [view]
Protein-Protein 155 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001047 core promoter binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0007623 circadian rhythm
GO:0008380 RNA splicing
GO:0042752 regulation of circadian rhythm
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0042382 paraspeckles
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031311
View Gene Order
ENSBTAG00000012152
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
circadianpathway
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533282 Hs.572371
RefSeq NM_001145408 NM_001145409 NM_001145410 NM_007363
HUGO
OMIM
CCDS CCDS14410 CCDS55445
HPRD 02098
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca