Homo sapiens Gene: PIGT
Summary
InnateDB Gene IDBG-77636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGT
Gene Name phosphatidylinositol glycan anchor biosynthesis, class T
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124155
Encoded Proteins
phosphatidylinositol glycan anchor biosynthesis, class T
phosphatidylinositol glycan anchor biosynthesis, class T
phosphatidylinositol glycan anchor biosynthesis, class T
phosphatidylinositol glycan anchor biosynthesis, class T
phosphatidylinositol glycan anchor biosynthesis, class T
phosphatidylinositol glycan anchor biosynthesis, class T
phosphatidylinositol glycan anchor biosynthesis, class T
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45416077-45426244
Strand Forward strand
Band q13.12
Transcripts
ENST00000279036 ENSP00000279036
ENST00000279035 ENSP00000279035
ENST00000372689 ENSP00000361774
ENST00000455050 ENSP00000407574
ENST00000432270 ENSP00000408354
ENST00000543458 ENSP00000441577
ENST00000545755 ENSP00000443963
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0016255 attachment of GPI anchor to protein
GO:0030182 neuron differentiation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0042765 GPI-anchor transamidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Attachment of GPI anchor to uPAR pathway
Post-translational modification: synthesis of GPI-anchored proteins pathway
Post-translational protein modification pathway
Metabolism of proteins pathway
KEGG
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437388
RefSeq NM_001184728 NM_001184729 NM_001184730 NM_015937
HUGO
OMIM
CCDS CCDS13353 CCDS54464 CCDS54465 CCDS54466
HPRD 15136
IMGT
EMBL
GenPept
RNA Seq Atlas