Version 5.4
Homo sapiens Gene: WFDC3
Summary
InnateDB Gene IDBG-77977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFDC3
Gene Name WAP four-disulfide core domain 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124116
Encoded Proteins
IDBP-77979
WAP four-disulfide core domain 3
IDBP-77981
WAP four-disulfide core domain 3
IDBP-77983
WAP four-disulfide core domain 3
IDBP-77989
WAP four-disulfide core domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45747944-45791932
Strand Reverse strand
Band q13.12
Transcripts
ENST00000243938 ENSP00000243938
ENST00000337205 ENSP00000337815
ENST00000372632 ENSP00000361715
ENST00000372630 ENSP00000361713
ENST00000481847
ENST00000471401
ENST00000493693
ENST00000474942
ENST00000487343
ENST00000462017
ENST00000467679
ENST00000490877
ENST00000465935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000076434
View Gene Order
ENSBTAG00000016742
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.419126 Hs.645202
RefSeq NM_080614
HUGO
OMIM
CCDS CCDS33478
HPRD 15676
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca