Version 5.4
Homo sapiens Gene: SYNC
Summary
InnateDB Gene IDBG-95790.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNC
Gene Name syncoilin, intermediate filament protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162520
Encoded Proteins
IDBP-95792
syncoilin, intermediate filament protein
IDBP-293926
syncoilin, intermediate filament protein
IDBP-379066
syncoilin, intermediate filament protein
IDBP-379071
syncoilin, intermediate filament protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:32680360-32703596
Strand Reverse strand
Band p35.1
Transcripts
ENST00000373484 ENSP00000362583
ENST00000409190 ENSP00000386439
ENST00000417633 ENSP00000401975
ENST00000426909 ENSP00000387594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0045103 intermediate filament-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0030018 Z disc
GO:0031594 neuromuscular junction
GO:0042383 sarcolemma
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001333
View Gene Order
ENSBTAG00000026684
Not yet available
Cross-References
SwissProt Q9H7C4
TrEMBL C9JSS1 C9JTN4
UniProt Splice Variant
Entrez Gene 81493
UniGene
RefSeq NM_001161708 NM_030786
HUGO HGNC:28897
OMIM 611750
CCDS CCDS53294 CCDS367
HPRD 18134
IMGT
EMBL AC114489 AK024707 AK297958 AK302275 BC119700 BC119701
GenPept AAI19701 AAI19702 BAB14970 BAG60270 BAG63620
RNA Seq Atlas 81493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca