InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PKN2

Summary

InnateDB Gene

IDBG-100129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKN2

Gene Name

protein kinase N2

Synonyms

Pak-2; PAK2; PRK2; PRKCL2; PRO2042; STK7;

Species

Homo sapiens

Ensembl Gene

ENSG00000065243

Encoded Proteins

IDBP-100131

protein kinase N2

IDBP-100133

protein kinase N2

IDBP-100137

protein kinase N2

IDBP-100139

protein kinase N2

IDBP-386486

protein kinase N2

IDBP-386488

protein kinase N2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:88684222-88836255

Strand

Forward strand

Band

p22.2

Transcripts

ENST00000370521	ENSP00000359552
ENST00000316005	ENSP00000317851
ENST00000370513	ENSP00000359544
ENST00000370505	ENSP00000359536
ENST00000436111	ENSP00000401125
ENST00000449189	ENSP00000389076
ENST00000495119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	44 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042826	histone deacetylase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0010631	epithelial cell migration
GO:0016310	phosphorylation
GO:0032467	positive regulation of cytokinesis
GO:0043297	apical junction assembly
GO:0045931	positive regulation of mitotic cell cycle
GO:0051301	cell division
GO:2000145	regulation of cell motility

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0043296	apical junction complex
GO:0045111	intermediate filament cytoskeleton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000004591

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000021900

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID BIOCARTA

PID NCI

rhoa_pathway

RhoA signaling pathway

Cross-References

SwissProt

TrEMBL

B1AL79

UniProt Splice Variant

Entrez Gene

5586

UniGene

Hs.440833 Hs.635447 Hs.703016

RefSeq

NM_006256

HUGO

HGNC:9406

OMIM

602549

CCDS

CCDS714

HPRD

03972

IMGT

EMBL

AC119426 AL136381 CH471097

GenPept

EAW73162

RNA Seq Atlas

5586