Homo sapiens Gene: DUOXA1
Summary
InnateDB Gene IDBG-10130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUOXA1
Gene Name dual oxidase maturation factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140254
Encoded Proteins
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:45117367-45129938
Strand Reverse strand
Band q21.1
Transcripts
ENST00000267803 ENSP00000267803
ENST00000430224 ENSP00000415512
ENST00000559014 ENSP00000453569
ENST00000558996 ENSP00000454019
ENST00000559013 ENSP00000453614
ENST00000558422 ENSP00000453836
ENST00000560572 ENSP00000454084
ENST00000558326 ENSP00000454117
ENST00000559988 ENSP00000453809
ENST00000559226 ENSP00000452782
ENST00000558377 ENSP00000453295
ENST00000559644 ENSP00000452795
ENST00000558851 ENSP00000453217
ENST00000559407
ENST00000558976
ENST00000613425 ENSP00000480154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0042743 hydrogen peroxide metabolic process
GO:0045666 positive regulation of neuron differentiation
GO:0050727 regulation of inflammatory response
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000609 regulation of thyroid hormone generation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL B5M0C0 H0YKF3 H0YNR1
UniProt Splice Variant
Entrez Gene 90527
UniGene
RefSeq NM_001276264 NM_001276265 NM_001276266 NM_001276267 NM_001276268 NM_144565 XM_005254773 XM_006720743 XM_006720744 XM_006720745 XM_006720746 XM_006720747 XM_006720748 XM_006720749 XM_006720750 XM_006720751 XM_006720752 XM_006720753 XM_006720754 XM_006720755 XM_006720756 XM_006720757
HUGO HGNC:26507
OMIM 612771
CCDS CCDS61620 CCDS10119 CCDS61619 CCDS61621
HPRD
IMGT
EMBL AC091117 EU927397
GenPept ACH57456
RNA Seq Atlas 90527