Homo sapiens Gene: DUOXA1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-10130.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | DUOXA1 | ||||||||||||||||||
Gene Name | dual oxidase maturation factor 1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000140254 | ||||||||||||||||||
Encoded Proteins |
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
dual oxidase maturation factor 1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 15:45117367-45129938 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q21.1 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.356664 | ||||||||||||||||||
RefSeq | NM_001276264 NM_001276265 NM_001276266 NM_001276267 NM_001276268 NM_144565 XM_005254773 XM_006720743 XM_006720744 XM_006720745 XM_006720746 XM_006720747 XM_006720748 XM_006720749 XM_006720750 XM_006720751 XM_006720752 XM_006720753 XM_006720754 XM_006720755 XM_006720756 XM_006720757 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS10119 CCDS61619 CCDS61620 CCDS61621 | ||||||||||||||||||
HPRD | 14829 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||