Homo sapiens Gene: ATP8B2
Summary
InnateDB Gene IDBG-102932.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP8B2
Gene Name ATPase, aminophospholipid transporter, class I, type 8B, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143515
Encoded Proteins
ATPase, class I, type 8B, member 2
ATPase, class I, type 8B, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154325553-154351307
Strand Forward strand
Band q21.3
Transcripts
ENST00000368490
ENST00000368489 ENSP00000357475
ENST00000368487 ENSP00000357472
ENST00000426445
ENST00000514107
ENST00000505882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006812 cation transport
GO:0015914 phospholipid transport
GO:0034220 ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0055085 transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435700
RefSeq NM_001005855 NM_020452 XM_005245355 XM_005245356
HUGO
OMIM
CCDS CCDS1066 CCDS41405
HPRD 05794
IMGT
EMBL
GenPept
RNA Seq Atlas