Homo sapiens Gene: EFNA1
Summary
InnateDB Gene IDBG-103097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFNA1
Gene Name ephrin-A1
Synonyms B61; ECKLG; EFL1; EPLG1; LERK-1; LERK1; TNFAIP4;
Species Homo sapiens
Ensembl Gene ENSG00000169242
Encoded Proteins
ephrin-A1
ephrin-A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155127460-155134857
Strand Forward strand
Band q22
Transcripts
ENST00000368407 ENSP00000357392
ENST00000368406 ENSP00000357391
ENST00000469878
ENST00000474413
ENST00000497282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0003180 aortic valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0014028 notochord formation
GO:0016477 cell migration
GO:0030182 neuron differentiation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0045765 regulation of angiogenesis
GO:0048013 ephrin receptor signaling pathway
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050770 regulation of axonogenesis
GO:0061002 negative regulation of dendritic spine morphogenesis
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Axon guidance pathway
EPHA-mediated growth cone collapse pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
EPHA forward signaling
HIF-2-alpha transcription factor network
EPHA2 forward signaling
Stabilization and expansion of the E-cadherin adherens junction
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516664
RefSeq NM_004428 NM_182685
HUGO
OMIM
CCDS CCDS1091 CCDS1092
HPRD 01858
IMGT
EMBL
GenPept
RNA Seq Atlas