Version 5.4
Homo sapiens Gene: EPHX1
Summary
InnateDB Gene IDBG-106969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHX1
Gene Name epoxide hydrolase 1, microsomal (xenobiotic)
Synonyms EPHX; EPOX; HYL1; MEH
Species Homo sapiens
Ensembl Gene ENSG00000143819
Encoded Proteins
IDBP-106971
epoxide hydrolase 1, microsomal (xenobiotic)
IDBP-106973
epoxide hydrolase 1, microsomal (xenobiotic)
IDBP-390078
epoxide hydrolase 1, microsomal (xenobiotic)
IDBP-390079
epoxide hydrolase 1, microsomal (xenobiotic)
IDBP-806649
epoxide hydrolase 1, microsomal (xenobiotic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:225810092-225845563
Strand Forward strand
Band q42.12
Transcripts
ENST00000272167 ENSP00000272167
ENST00000366837 ENSP00000355802
ENST00000445856 ENSP00000398491
ENST00000448202 ENSP00000408469
ENST00000467015
ENST00000614058 ENSP00000480004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004301 epoxide hydrolase activity
GO:0033961 cis-stilbene-oxide hydrolase activity
Biological Process
GO:0006725 cellular aromatic compound metabolic process
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0019439 aromatic compound catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038776
View Gene Order
ENSBTAG00000000140
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.741803 Hs.89649
RefSeq NM_000120 NM_001136018 NM_001291163
HUGO
OMIM
CCDS CCDS1547
HPRD 00581
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca