Homo sapiens Gene: BIRC2
InnateDB Gene IDBG-69075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIRC2
Gene Name baculoviral IAP repeat containing 2
Synonyms API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; RNF48
Species Homo sapiens
Ensembl Gene ENSG00000110330
Encoded Proteins
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
baculoviral IAP repeat containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
BIRC2 regulates TNF-alpha(TNF)-mediated NF-kappaB activation by binding to TNFRSF1A (TNF receptor 1).
BIRC2 is the ubiquitin protein ligase for ASK1 ubiquitination, a protein that plays an essential role in tumour necrosis factor alpha (TNF-alpha)-induced mitogen-activated protein kinase signalling. BIRC2 is also responsible for regulating the duration of TNF signalling in primary cells expressing TNFR2.
BIRC2 and BIRC3 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.
BIRC2 plays a role in lipopolysaccharide (LPS)-induced autophagy in vascular endothelial cells (VECs).
BIRC2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
InnateDB Annotation from Orthologs
[Mus musculus] Birc2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
Entrez Gene
Summary The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102347211-102378670
Strand Forward strand
Band q22.2
ENST00000227758 ENSP00000227758
ENST00000532832 ENSP00000432410
ENST00000530675 ENSP00000431723
ENST00000533742 ENSP00000433851
ENST00000532672 ENSP00000434979
ENST00000531259 ENSP00000436741
ENST00000527465 ENSP00000434708
ENST00000528344 ENSP00000434557
ENST00000613397 ENSP00000477613
ENST00000621637 ENSP00000484838
Number of Interactions This gene and/or its encoded proteins are associated with 184 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 184 [view]
Protein-Protein 179 [view]
Protein-DNA 5 [view]
Protein-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001666 response to hypoxia
GO:0001890 placenta development
GO:0002224 toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007166 cell surface receptor signaling pathway
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0039535 regulation of RIG-I signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0045471 response to ethanol
GO:0045595 regulation of cell differentiation
GO:0050727 regulation of inflammatory response
GO:0051291 protein heterooligomerization
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0070266 necroptotic process
GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1902524 positive regulation of protein K48-linked ubiquitination
GO:1902527 positive regulation of protein monoubiquitination
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0001741 XY body
GO:0005634 nucleus
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0043234 protein complex
GO:0045121 membrane raft
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
TNFalpha pathway
TWEAK pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
NOD1/2 Signaling Pathway pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Apoptosis pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Apoptosis pathway
Ubiquitin mediated proteolysis pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
NOD-like receptor signaling pathway pathway
Toxoplasmosis pathway
CD40/CD40L signaling
TNF receptor signaling pathway
Canonical NF-kappaB pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.696238 Hs.731943
RefSeq NM_001166 NM_001256163 NM_001256166
HPRD 03419
RNA Seq Atlas