Version 5.4
Mus musculus Gene: Cd36
Summary
InnateDB Gene IDBG-136838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd36
Gene Name CD36 antigen
Synonyms FAT; GPIV; Scarb3
Species Mus musculus
Ensembl Gene ENSMUSG00000002944
Encoded Proteins
IDBP-136840
CD36 antigen
IDBP-623611
CD36 antigen
IDBP-623612
CD36 antigen
IDBP-623613
CD36 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24257313
MSR1 and Cd36 share several ligands and are involved in largely overlapping physiological and pathological processes, but they differ significantly in their effects on proinflammatory and immunoregulatory functions of macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 19237602
[Homo sapiens] CD36 mediates host defence against Cryptococcus neoformans and Candida albicans through cytokine production.
PMID 19847289
[Homo sapiens] CD36 ectodomain binds negatively charged diacylglycerol ligands and CD36, along with CD14, has a non-redundant role for loading ligands onto TLR2 in the plasma-membrane.
PMID 15690042
[Homo sapiens] CD36 is a selective and non-redundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer.
PMID 20037584
[Homo sapiens] CD36-TLR4-TLR6 activation is a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135218:
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:17781690-17888959
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000082367 ENSMUSP00000080974
ENSMUST00000169095 ENSMUSP00000131832
ENSMUST00000165232 ENSMUSP00000126300
ENSMUST00000170051 ENSMUSP00000133008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005515 protein binding
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0030169 low-density lipoprotein particle binding
GO:0070892 lipoteichoic acid receptor activity
GO:0071813 lipoprotein particle binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002221 pattern recognition receptor signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0006910 phagocytosis, recognition
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0010629 negative regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010886 positive regulation of cholesterol storage
GO:0015911 plasma membrane long-chain fatty acid transport
GO:0019915 lipid storage
GO:0019934 cGMP-mediated signaling
GO:0030194 positive regulation of blood coagulation
GO:0030301 cholesterol transport
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034381 plasma lipoprotein particle clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0035634 response to stilbenoid
GO:0042953 lipoprotein transport
GO:0042992 negative regulation of transcription factor import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277 apoptotic cell clearance
GO:0043410 positive regulation of MAPK cascade
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0044130 negative regulation of growth of symbiont in host
GO:0044539 long-chain fatty acid import
GO:0045087 innate immune response (InnateDB)
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830 defense response to Gram-positive bacterium
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060907 positive regulation of macrophage cytokine production
GO:0071221 cellular response to bacterial lipopeptide
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071447 cellular response to hydroperoxide
GO:2000121 regulation of removal of superoxide radicals
GO:2000334 positive regulation of blood microparticle formation
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135218
View Gene Order
ENSBTAG00000017866
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_224553
Hemostasis pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_199093
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_229531
Adaptive Immune System pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_196592
Scavenging by Class B Receptors pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu03320
PPAR signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu05144
Malaria pathway
mmu04145
Phagosome pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111174
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_163679
Scavenging by Class B Receptors pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
REACT_202252
Platelet degranulation pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_218962
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_214469
Adaptive Immune System pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_207237
PPARA activates gene expression pathway
REACT_216714
Innate Immune System pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_218645
Antigen processing-Cross presentation pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_227409
Scavenging by Class B Receptors pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04512
ECM-receptor interaction pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05144
Malaria pathway
hsa04975
Fat digestion and absorption pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q08857
TrEMBL Q3U6Y9 Q3UAI3 Q9CT95
UniProt Splice Variant
Entrez Gene 12491
UniGene Mm.18628 Mm.406602 Mm.406799
RefSeq NM_001159558 XM_006535620 XM_006535624 XM_006535625 NM_001159555 NM_001159556 NM_001159557 NM_007643 XM_006535621 XM_006535622 XM_006535623
OMIM
CCDS CCDS19100
HPRD
IMGT
MGI ID MGI:107899
MGI Symbol Cd36
EMBL AK004192 AK151355 AK152904 BC010262 CH466586 L23108
GenPept AAA53028 AAH10262 BAB23215 BAE30331 BAE31585 EDL03230 EDL03231 EDL03232
RNA Seq Atlas 12491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca