Version 5.4
Homo sapiens Gene: CLEC5A
Summary
InnateDB Gene IDBG-546985.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC5A
Gene Name C-type lectin domain family 5, member A
Synonyms CLECSF5; MDL-1; MDL1
Species Homo sapiens
Ensembl Gene ENSG00000258227
Encoded Proteins
IDBP-386892
C-type lectin domain family 5, member A
IDBP-386893
C-type lectin domain family 5, member A
IDBP-386895
C-type lectin domain family 5, member A
IDBP-590420
C-type lectin domain family 5, member A
IDBP-584752
C-type lectin domain family 5, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141927357-141947007
Strand Reverse strand
Band q34
Transcripts
ENST00000418498 ENSP00000392561
ENST00000439991 ENSP00000395258
ENST00000438351 ENSP00000414897
ENST00000470595
ENST00000481301
ENST00000546910 ENSP00000449999
ENST00000551012 ENSP00000446890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002076 osteoblast development
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0009615 response to virus
GO:0016032 viral process
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029915
View Gene Order
ENSBTAG00000020453
Not yet available
Pathways
NETPATH
REACTOME
REACT_147694
DAP12 interactions pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446235
RefSeq NM_001301167 NM_013252 XM_005249965
HUGO
OMIM
CCDS CCDS5870 CCDS75670
HPRD 09229
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca