InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccrn4l

Summary

InnateDB Gene

IDBG-142661.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccrn4l

Gene Name

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

Synonyms

AU043840; Ccr4; nocturnin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023087

Encoded Proteins

IDBP-142663

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

IDBP-624957

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151014:
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:51224447-51251644

Strand

Forward strand

Band

Transcripts

ENSMUST00000023849	ENSMUSP00000023849
ENSMUST00000144826
ENSMUST00000167780	ENSMUSP00000130347

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006397	mRNA processing
GO:0007623	circadian rhythm
GO:0009991	response to extracellular stimulus
GO:0010629	negative regulation of gene expression
GO:0032496	response to lipopolysaccharide
GO:0032922	circadian regulation of gene expression
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0042752	regulation of circadian rhythm
GO:0045600	positive regulation of fat cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045995	regulation of embryonic development
GO:0048255	mRNA stabilization
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151014

View Gene Order

ENSBTAG00000005998

Not yet available

Pathways

NETPATH

REACTOME

REACT_241925

Circadian Clock pathway

REACT_198620

BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_111118

BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway

REACT_24941

Circadian Clock pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.422145 Mm.474178 Mm.86541

RefSeq

NM_009834 XM_006500956

OMIM

CCDS

CCDS17336

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas