InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Xbp1

Summary

InnateDB Gene

IDBG-144745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xbp1

Gene Name

X-box binding protein 1

Synonyms

D11Ertd39e; TREB-5; TREB5; XBP-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020484

Encoded Proteins

IDBP-144747

X-box binding protein 1

IDBP-717247

IDBP-625915

X-box binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20351694

Xbp1 transcription factor regulates innate immune responses in macrophages via Tlr2 activation and its deficiency results in a much greater bacterial burden in mice infected with the Tlr2-activating human intracellular pathogen Francisella tularensis.

PMID 21400498

Xbp1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. Xbp1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of Xbp1 synergistically augments the poly(I:C)-induced inflammatory response.

InnateDB Annotation from Orthologs

Summary

PMID 20351694

[Homo sapiens] XBP1 transcription factor regulates innate immune responses in macrophages via TLR2 activation and its deficiency results in a much greater bacterial burden in mice infected with the TLR2-activating human intracellular pathogen Francisella tularensis.

PMID 20533428

[Homo sapiens] XBP1/ERN1 (IRE1)-mediated signalling plays roles in the coordination of metabolic and immune responses by acting as a regulatory hub, linking endoplasmic reticulum homeostasis with innate immunity and metabolism.

PMID 20660350

[Homo sapiens] XBP1 interacts with EP300 to augment IFN-beta induction via a cis-acting enhancer in macrophages under endoplasmic reticulum stress.

PMID 21400498

[Homo sapiens] XBP1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. XBP1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of XBP1 synergistically augments the poly(I:C)-induced inflammatory response. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100219:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:5520659-5525893

Strand

Forward strand

Band

Transcripts

ENSMUST00000063084	ENSMUSP00000054852
ENSMUST00000145588
ENSMUST00000149623	ENSMUSP00000135768
ENSMUST00000149159	ENSMUSP00000134088

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002070	epithelial cell maturation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031017	exocrine pancreas development
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051602	response to electrical stimulus
GO:0060096	serotonin secretion, neurotransmission
GO:0060691	epithelial cell maturation involved in salivary gland development
GO:0071236	cellular response to antibiotic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
GO:1901800	positive regulation of proteasomal protein catabolic process