Version 5.4
Mus musculus Gene: Hadhb
Summary
InnateDB Gene IDBG-145305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hadhb
Gene Name hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000059447
Encoded Proteins
IDBP-145307
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
IDBP-250986
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
IDBP-250988
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
IDBP-539361
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138029:
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Alternatively spliced transcript variants have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:30155248-30184593
Strand Forward strand
Band B1
Transcripts
ENSMUST00000026841 ENSMUSP00000026841
ENSMUST00000114786 ENSMUSP00000110434
ENSMUST00000114783 ENSMUSP00000110431
ENSMUST00000123980 ENSMUSP00000118296
ENSMUST00000127364
ENSMUST00000122934
ENSMUST00000133414
ENSMUST00000141236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003824 catalytic activity
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005515 protein binding
GO:0016508 long-chain-enoyl-CoA hydratase activity
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032403 protein complex binding
GO:0044822 poly(A) RNA binding
GO:0051287 NAD binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138029
View Gene Order
ENSBTAG00000010083
Not yet available
Pathways
NETPATH
REACTOME
REACT_199034
Acyl chain remodeling of CL pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_233858
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_237597
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_188937
Metabolism pathway
REACT_236353
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_261839
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_257646
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_256910
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_239107
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
REACT_251878
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
KEGG
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00062
Fatty acid elongation pathway
mmu00071
Fatty acid degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121006
Acyl chain remodeling of CL pathway
REACT_1887
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_2108
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_2025
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
REACT_735
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_1697
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_1708
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
REACT_214604
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_208669
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_226164
Acyl chain remodeling of CL pathway
REACT_211406
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_225673
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_221200
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_201892
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_219139
Metabolism pathway
REACT_218329
Phospholipid metabolism pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_220229
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_202075
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00071
Fatty acid degradation pathway
hsa00062
Fatty acid elongation pathway
INOH
INOH website
Valine Leucine Isoleucine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.291463 Mm.395009 Mm.405989
RefSeq NM_001289798 NM_001289799 NM_145558 XM_006535705 XM_006535706
OMIM
CCDS CCDS39045
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca