InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smc2

Summary

InnateDB Gene

IDBG-147370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smc2

Gene Name

structural maintenance of chromosomes 2

Synonyms

5730502P04Rik; AI255214; AW545314; CAP-E; CAPE; Fin16; SMC-2; Smc2l1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028312

Encoded Proteins

IDBP-147372

structural maintenance of chromosomes 2

IDBP-400956

structural maintenance of chromosomes 2

IDBP-539750

structural maintenance of chromosomes 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:52439243-52488260

Strand

Forward strand

Band

Transcripts

ENSMUST00000102915	ENSMUSP00000099979
ENSMUST00000117280	ENSMUSP00000113940
ENSMUST00000131163
ENSMUST00000146787
ENSMUST00000142227	ENSMUSP00000114228

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007076	mitotic chromosome condensation
GO:0010032	meiotic chromosome condensation
GO:0045132	meiotic chromosome segregation
GO:0051276	chromosome organization
GO:0051383	kinetochore organization

Cellular Component

GO:0000228	nuclear chromosome
GO:0000793	condensed chromosome
GO:0000796	condensin complex
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome