Mus musculus Gene: Gpsm1
Summary
InnateDB Gene IDBG-148192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpsm1
Gene Name G-protein signalling modulator 1 (AGS3-like, C. elegans)
Synonyms 1810037C22Rik; Ags3; AW107933;
Species Mus musculus
Ensembl Gene ENSMUSG00000026930
Encoded Proteins
G-protein signalling modulator 1 (AGS3-like, C. elegans)
G-protein signalling modulator 1 (AGS3-like, C. elegans)
G-protein signalling modulator 1 (AGS3-like, C. elegans)
G-protein signalling modulator 1 (AGS3-like, C. elegans)
G-protein signalling modulator 1 (AGS3-like, C. elegans)
G-protein signalling modulator 1 (AGS3-like, C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Gpsm1, an inhibitor of Gnai3, plays a key role in regulating autophagy; the dynamic interplay between Gnai3, Gpsm1, and Ccdc88a determines whether autophagy is promoted or inhibited. During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signaling pathways.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] GPSM1, an inhibitor of GNAI3, plays a key role in regulating autophagy; the dynamic interplay between GNAI3, GPSM1, and CCDC88A determines whether autophagy is promoted or inhibited. During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160360:
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:26315515-26348237
Strand Forward strand
Band A3
Transcripts
ENSMUST00000066936 ENSMUSP00000065000
ENSMUST00000078616 ENSMUSP00000077686
ENSMUST00000066889 ENSMUSP00000067964
ENSMUST00000114134 ENSMUSP00000109769
ENSMUST00000145884 ENSMUSP00000115680
ENSMUST00000132638
ENSMUST00000152895
ENSMUST00000153064
ENSMUST00000127453 ENSMUSP00000120934
ENSMUST00000123981
ENSMUST00000132276
ENSMUST00000147873
ENSMUST00000142057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005515 protein binding
GO:0030695 GTPase regulator activity
Biological Process
GO:0007399 nervous system development
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.266611
RefSeq NM_001199146 NM_001199147 NM_153410 XM_006498253 XM_006498254
OMIM
CCDS CCDS15800 CCDS57158 CCDS57159
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas