Version 5.4
Mus musculus Gene: Cnot7
Summary
InnateDB Gene IDBG-149815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnot7
Gene Name CCR4-NOT transcription complex, subunit 7
Synonyms AU022737; CAF-1; Caf1; Pop2
Species Mus musculus
Ensembl Gene ENSMUSG00000031601
Encoded Proteins
IDBP-149817
CCR4-NOT transcription complex, subunit 7
IDBP-537365
CCR4-NOT transcription complex, subunit 7
IDBP-537561
CCR4-NOT transcription complex, subunit 7
IDBP-535194
CCR4-NOT transcription complex, subunit 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198791:
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:40492540-40515847
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000034012 ENSMUSP00000034012
ENSMUST00000132032 ENSMUSP00000122933
ENSMUST00000144970
ENSMUST00000135269 ENSMUSP00000119319
ENSMUST00000149992 ENSMUSP00000117304
ENSMUST00000142455
ENSMUST00000132740
ENSMUST00000132200
ENSMUST00000146280
ENSMUST00000128237
ENSMUST00000139558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006351 transcription, DNA-templated
GO:0006417 regulation of translation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0031047 gene silencing by RNA
GO:0033962 cytoplasmic mRNA processing body assembly
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198791
View Gene Order
ENSBTAG00000018036
Not yet available
Pathways
NETPATH
REACTOME
REACT_244119
Deadenylation of mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
REACT_224454
Deadenylation of mRNA pathway
REACT_226022
Gene Expression pathway
REACT_203426
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272551 Mm.412935
RefSeq NM_001271542 NM_001271543 NM_011135
OMIM
CCDS CCDS22253 CCDS72114
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca