Version 5.4
Homo sapiens Gene: CNOT7
Summary
InnateDB Gene IDBG-8558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT7
Gene Name CCR4-NOT transcription complex, subunit 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198791
Encoded Proteins
IDBP-8564
CCR4-NOT transcription complex, subunit 7
IDBP-481543
CCR4-NOT transcription complex, subunit 7
IDBP-474554
CCR4-NOT transcription complex, subunit 7
IDBP-482690
CCR4-NOT transcription complex, subunit 7
IDBP-477539
CCR4-NOT transcription complex, subunit 7
IDBP-483829
CCR4-NOT transcription complex, subunit 7
IDBP-479329
CCR4-NOT transcription complex, subunit 7
IDBP-473927
CCR4-NOT transcription complex, subunit 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:17224964-17246878
Strand Reverse strand
Band p22
Transcripts
ENST00000361272 ENSP00000355279
ENST00000518541 ENSP00000430263
ENST00000523917 ENSP00000429093
ENST00000519954 ENSP00000429632
ENST00000519918 ENSP00000428147
ENST00000522062
ENST00000524358 ENSP00000430160
ENST00000519998
ENST00000518021 ENSP00000428783
ENST00000520178 ENSP00000429079
ENST00000518885
ENST00000523649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0005975 carbohydrate metabolic process
GO:0006351 transcription, DNA-templated
GO:0006417 regulation of translation
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:0033962 cytoplasmic mRNA processing body assembly
GO:0035195 gene silencing by miRNA
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031601
View Gene Order
ENSBTAG00000018036
Not yet available
Pathways
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.645009 Hs.711543
RefSeq NM_013354 NM_054026 XM_005273481
HUGO
OMIM
CCDS CCDS55202 CCDS6000
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca