Version 5.4
Mus musculus Gene: Htr4
Summary
InnateDB Gene IDBG-152682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Htr4
Gene Name 5 hydroxytryptamine (serotonin) receptor 4
Synonyms 5-HT-4; 5-HT<4L>; 5-HT4; 5HTR4
Species Mus musculus
Ensembl Gene ENSMUSG00000026322
Encoded Proteins
IDBP-152684
5 hydroxytryptamine (serotonin) receptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164270:
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:62324204-62467802
Strand Forward strand
Band E1
Transcripts
ENSMUST00000027560 ENSMUSP00000027560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007268 synaptic transmission
GO:0008284 positive regulation of cell proliferation
GO:0032098 regulation of appetite
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164270
View Gene Order
ENSBTAG00000010837
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_252999
Amine ligand-binding receptors pathway
REACT_232980
Serotonin receptors pathway
REACT_231468
GPCR ligand binding pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_17064
Serotonin receptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P97288
TrEMBL
UniProt Splice Variant
Entrez Gene 15562
UniGene Mm.20440
RefSeq NM_008313 XM_006525675 XM_006525676 XM_006525677 XM_006525678 XM_006525679
OMIM
CCDS CCDS29291
HPRD
IMGT
MGI ID MGI:109246
MGI Symbol Htr4
EMBL AJ011369 AK141587 AK141625 CH466528 Y09585 Y09587 Y09588
GenPept BAE24750 BAE24773 CAA09598 CAA70773 CAA70775 CAA70776 EDL09743
RNA Seq Atlas 15562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca