InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lgals3

Summary

InnateDB Gene

IDBG-154384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lgals3

Gene Name

lectin, galactose binding, soluble 3

Synonyms

gal3; GBP; L-34; Mac-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050335

Encoded Proteins

IDBP-541456

lectin, galactose binding, soluble 3

IDBP-533858

lectin, galactose binding, soluble 3

IDBP-533749

lectin, galactose binding, soluble 3

IDBP-537005

lectin, galactose binding, soluble 3

IDBP-539112

lectin, galactose binding, soluble 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22486577

Lgals3 influences the course of malaria in a Plasmodium species-specific manner.

PMID 26857579

Lgals3 plays an important role in innate immunity to infection and colonization of Helicobacter pylori.

InnateDB Annotation from Orthologs

Summary

PMID 18825751

[Homo sapiens] LGALS3 exerts a regulatory role in innate immunity by diminishing IL-1beta production and thus affecting resistance to Rhodococcus equi infection.

PMID 19951367

[Homo sapiens] LGALS3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection.

PMID 20208507

[Homo sapiens] LGALS3 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.

PMID 22486577

[Homo sapiens] LGALS3 influences the course of malaria in a Plasmodium species-specific manner. (Demonstrated in mice)

PMID 26589797

[Homo sapiens] LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131981:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:47367751-47386160

Strand

Forward strand

Band

Transcripts

ENSMUST00000151405	ENSMUSP00000118660
ENSMUST00000142734	ENSMUSP00000118169
ENSMUST00000150290	ENSMUSP00000114350
ENSMUST00000144794	ENSMUSP00000114177
ENSMUST00000146468	ENSMUSP00000119275

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019863	IgE binding
GO:0030246	carbohydrate binding
GO:0042056	chemoattractant activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001501	skeletal system development
GO:0002548	monocyte chemotaxis
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0030855	epithelial cell differentiation
GO:0042129	regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis
GO:0048245	eosinophil chemotaxis
GO:0048246	macrophage chemotaxis
GO:0050918	positive chemotaxis
GO:0070232	regulation of T cell apoptotic process
GO:0071674	mononuclear cell migration
GO:0071677	positive regulation of mononuclear cell migration
GO:0090280	positive regulation of calcium ion import
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000131981

View Gene Order

ENSBTAG00000002326

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25195

Advanced glycosylation endproduct receptor signaling pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

hedgehog_glipathway

Hedgehog signaling events mediated by Gli proteins

Cross-References

SwissProt

TrEMBL

D3YVT4 D3YZJ2 Q8C253

UniProt Splice Variant

Entrez Gene

16854

UniGene

Mm.248615 Mm.486633

RefSeq

NM_001145953 NM_010705

OMIM

CCDS

CCDS26986

HPRD

IMGT

MGI ID

MGI:96778

MGI Symbol

Lgals3

EMBL

AC123665 AK089249 AK149783 AK155484 AK159536 AK170803 BC132328 BC138790 BC145419 CH466605

GenPept

AAI32329 AAI38791 AAI45420 BAC40813 BAE29081 BAE33287 BAE35163 BAE42038 EDL20742 EDL20745

RNA Seq Atlas

16854