Mus musculus Gene: Lgals3
Summary
InnateDB Gene IDBG-154384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lgals3
Gene Name lectin, galactose binding, soluble 3
Synonyms gal3; GBP; L-34; Mac-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000050335
Encoded Proteins
lectin, galactose binding, soluble 3
lectin, galactose binding, soluble 3
lectin, galactose binding, soluble 3
lectin, galactose binding, soluble 3
lectin, galactose binding, soluble 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Lgals3 influences the course of malaria in a Plasmodium species-specific manner.
Lgals3 plays an important role in innate immunity to infection and colonization of Helicobacter pylori.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] LGALS3 exerts a regulatory role in innate immunity by diminishing IL-1beta production and thus affecting resistance to Rhodococcus equi infection.
[Homo sapiens] LGALS3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection.
[Homo sapiens] LGALS3 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
[Homo sapiens] LGALS3 influences the course of malaria in a Plasmodium species-specific manner. (Demonstrated in mice)
[Homo sapiens] LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131981:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:47367751-47386160
Strand Forward strand
Band C1
Transcripts
ENSMUST00000151405 ENSMUSP00000118660
ENSMUST00000142734 ENSMUSP00000118169
ENSMUST00000150290 ENSMUSP00000114350
ENSMUST00000144794 ENSMUSP00000114177
ENSMUST00000146468 ENSMUSP00000119275
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 55 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019863 IgE binding
GO:0030246 carbohydrate binding
GO:0042056 chemoattractant activity
GO:0043236 laminin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001501 skeletal system development
GO:0002548 monocyte chemotaxis
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0030855 epithelial cell differentiation
GO:0042129 regulation of T cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045806 negative regulation of endocytosis
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0050918 positive chemotaxis
GO:0070232 regulation of T cell apoptotic process
GO:0071674 mononuclear cell migration
GO:0071677 positive regulation of mononuclear cell migration
GO:0090280 positive regulation of calcium ion import
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
Advanced glycosylation endproduct receptor signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of Ras family activation
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL D3YVT4 D3YZJ2 Q8C253
UniProt Splice Variant
Entrez Gene 16854
UniGene Mm.248615 Mm.486633
RefSeq NM_001145953 NM_010705
OMIM
CCDS CCDS26986
HPRD
IMGT
MGI ID MGI:96778
MGI Symbol Lgals3
EMBL AC123665 AK089249 AK149783 AK155484 AK159536 AK170803 BC132328 BC138790 BC145419 CH466605
GenPept AAI32329 AAI38791 AAI45420 BAC40813 BAE29081 BAE33287 BAE35163 BAE42038 EDL20742 EDL20745
RNA Seq Atlas 16854