Bos taurus Gene: NCF4
Summary
InnateDB Gene IDBG-638107.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCF4
Gene Name neutrophil cytosol factor 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007531
Encoded Proteins
neutrophil cytosol factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100365:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:75641217-75659769
Strand Forward strand
Band
Transcripts
ENSBTAT00000009911 ENSBTAP00000009911
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0043020 NADPH oxidase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by VEGF pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Signal Transduction pathway
Antigen processing-Cross presentation pathway
Phagosomal maturation (early endosomal stage) pathway
Adaptive Immune System pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Class I MHC mediated antigen processing & presentation pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Signaling by VEGF pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Antigen processing-Cross presentation pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Adaptive Immune System pathway
Signal Transduction pathway
KEGG
Phagosome pathway
Osteoclast differentiation pathway
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
Phagosome pathway
Osteoclast differentiation pathway
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.7625
RefSeq NM_001045983
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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