Homo sapiens Gene: NCF4 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-6112.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | NCF4 | ||||||||||||||||||||||
Gene Name | neutrophil cytosolic factor 4, 40kDa | ||||||||||||||||||||||
Synonyms | NCF; P40PHOX; SH3PXD4 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000100365 | ||||||||||||||||||||||
Encoded Proteins |
neutrophil cytosolic factor 4, 40kDa
neutrophil cytosolic factor 4, 40kDa
neutrophil cytosolic factor 4, 40kDa
neutrophil cytosolic factor 4, 40kDa
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 22:36860988-36878015 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q12.3 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by VEGF pathway
Signal Transduction pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Class I MHC mediated antigen processing & presentation pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
|
||||||||||||||||||||||
KEGG |
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Phagosome pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 4689 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_000631 NM_013416 | ||||||||||||||||||||||
HUGO | HGNC:7662 | ||||||||||||||||||||||
OMIM | 601488 | ||||||||||||||||||||||
CCDS | CCDS13934 CCDS13935 | ||||||||||||||||||||||
HPRD | 03289 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 4689 | ||||||||||||||||||||||