InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AR

Summary

InnateDB Gene

IDBG-73722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

androgen receptor

Synonyms

AIS; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM

Species

Homo sapiens

Ensembl Gene

ENSG00000169083

Encoded Proteins

IDBP-73724

androgen receptor

IDBP-238328

androgen receptor

IDBP-238330

androgen receptor

IDBP-482695

androgen receptor

IDBP-483714

androgen receptor

IDBP-809245

androgen receptor

IDBP-809247

androgen receptor

IDBP-809248

androgen receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:67544032-67730619

Strand

Forward strand

Band

q12

Transcripts

ENST00000374690	ENSP00000363822
ENST00000396044	ENSP00000379359
ENST00000396043	ENSP00000379358
ENST00000513847
ENST00000504326	ENSP00000421155
ENST00000514029	ENSP00000425199
ENST00000613054	ENSP00000479013
ENST00000612010	ENSP00000482407
ENST00000612452	ENSP00000484033

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 453 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	453 [view]
Protein-Protein	433 [view]
Protein-DNA	15 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004882	androgen receptor activity
GO:0005102	receptor binding
GO:0005496	steroid binding
GO:0005497	androgen binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0050681	androgen receptor binding
GO:0070974	POU domain binding

Biological Process

GO:0001701	in utero embryonic development
GO:0003073	regulation of systemic arterial blood pressure
GO:0003382	epithelial cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006810	transport
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0007548	sex differentiation
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009566	fertilization
GO:0009987	cellular process
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0016049	cell growth
GO:0019102	male somatic sex determination
GO:0030521	androgen receptor signaling pathway
GO:0030522	intracellular receptor signaling pathway
GO:0030850	prostate gland development
GO:0032868	response to insulin
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0033327	Leydig cell differentiation
GO:0035264	multicellular organism growth
GO:0042327	positive regulation of phosphorylation
GO:0043401	steroid hormone mediated signaling pathway
GO:0043410	positive regulation of MAPK cascade
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045720	negative regulation of integrin biosynthetic process
GO:0045726	positive regulation of integrin biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0046661	male sex differentiation
GO:0048608	reproductive structure development
GO:0048638	regulation of developmental growth
GO:0048645	organ formation
GO:0048808	male genitalia morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050790	regulation of catalytic activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051259	protein oligomerization
GO:0060520	activation of prostate induction by androgen receptor signaling pathway
GO:0060571	morphogenesis of an epithelial fold
GO:0060599	lateral sprouting involved in mammary gland duct morphogenesis
GO:0060685	regulation of prostatic bud formation
GO:0060736	prostate gland growth
GO:0060740	prostate gland epithelium morphogenesis
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0060748	tertiary branching involved in mammary gland duct morphogenesis
GO:0060749	mammary gland alveolus development
GO:0061458	reproductive system development
GO:0071383	cellular response to steroid hormone stimulus
GO:0072520	seminiferous tubule development
GO:0090003	regulation of establishment of protein localization to plasma membrane
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043234	protein complex