Mus musculus Gene: Ogt
Summary
InnateDB Gene IDBG-164680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ogt
Gene Name O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Synonyms 1110038P24Rik; 4831420N21Rik; AI115525; Ogtl;
Species Mus musculus
Ensembl Gene ENSMUSG00000034160
Encoded Proteins
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147162:
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:101640060-101684351
Strand Forward strand
Band D
Transcripts
ENSMUST00000044475 ENSMUSP00000045409
ENSMUST00000119299 ENSMUSP00000113454
ENSMUST00000155713
ENSMUST00000153979
ENSMUST00000150161
ENSMUST00000155792
ENSMUST00000147635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008047 enzyme activator activity
GO:0008080 N-acetyltransferase activity
GO:0016262 protein N-acetylglucosaminyltransferase activity
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
GO:0097363 protein O-GlcNAc transferase activity
Biological Process
GO:0006110 regulation of glycolytic process
GO:0006493 protein O-linked glycosylation
GO:0006915 apoptotic process
GO:0030854 positive regulation of granulocyte differentiation
GO:0031397 negative regulation of protein ubiquitination
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0035020 regulation of Rac protein signal transduction
GO:0043085 positive regulation of catalytic activity
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045862 positive regulation of proteolysis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046626 regulation of insulin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
GO:0071300 cellular response to retinoic acid
GO:0080182 histone H3-K4 trimethylation
GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070688 MLL5-L complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Chromatin organization pathway
HATs acetylate histones pathway
Chromatin modifying enzymes pathway
KEGG
Other types of O-glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
HATs acetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
Other types of O-glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8CGY8
TrEMBL
UniProt Splice Variant
Entrez Gene 108155
UniGene Mm.476355 Mm.487332 Mm.489879
RefSeq NM_001290535 NM_139144 XM_006527736 XM_006527737 XM_006527738
OMIM
CCDS CCDS30318 CCDS72415
HPRD
IMGT
MGI ID MGI:1339639
MGI Symbol Ogt
EMBL AF363030 AF539527 AK047095 AL805980 AL806534 BC057319
GenPept AAH57319 AAK39123 AAO17363 BAC32961 CAM21281 CAM21282 CAM25748 CAM25749
RNA Seq Atlas 108155