InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pkd2l1

Summary

InnateDB Gene

IDBG-169468.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pkd2l1

Gene Name

polycystic kidney disease 2-like 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037578

Encoded Proteins

IDBP-169470

polycystic kidney disease 2-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107593:
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44147637-44192442

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042026	ENSMUSP00000045675
ENSMUST00000161357

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005272	sodium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008324	cation transmembrane transporter activity
GO:0015269	calcium-activated potassium channel activity
GO:0033040	sour taste receptor activity
GO:0042802	identical protein binding
GO:0051371	muscle alpha-actinin binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007224	smoothened signaling pathway
GO:0035725	sodium ion transmembrane transport
GO:0050915	sensory perception of sour taste
GO:0050982	detection of mechanical stimulus
GO:0055085	transmembrane transport
GO:0070207	protein homotrimerization
GO:0070588	calcium ion transmembrane transport
GO:0071468	cellular response to acidity
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0031513	nonmotile primary cilium
GO:0034704	calcium channel complex
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107593

View Gene Order

ENSBTAG00000010742

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.308481

RefSeq

NM_181422 XM_006527141 XM_006527142 XM_006527143

OMIM

CCDS

CCDS29846

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas