Mus musculus Gene: Pkd2l1
Summary
InnateDB Gene IDBG-169468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pkd2l1
Gene Name polycystic kidney disease 2-like 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037578
Encoded Proteins
polycystic kidney disease 2-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107593:
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:44147637-44192442
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000042026 ENSMUSP00000045675
ENSMUST00000161357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008324 cation transmembrane transporter activity
GO:0015269 calcium-activated potassium channel activity
GO:0033040 sour taste receptor activity
GO:0042802 identical protein binding
GO:0051371 muscle alpha-actinin binding
GO:0051393 alpha-actinin binding
Biological Process
GO:0001581 detection of chemical stimulus involved in sensory perception of sour taste
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007224 smoothened signaling pathway
GO:0035725 sodium ion transmembrane transport
GO:0050915 sensory perception of sour taste
GO:0050982 detection of mechanical stimulus
GO:0055085 transmembrane transport
GO:0070207 protein homotrimerization
GO:0070588 calcium ion transmembrane transport
GO:0071468 cellular response to acidity
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031513 nonmotile primary cilium
GO:0034704 calcium channel complex
GO:0043231 intracellular membrane-bounded organelle
GO:0060170 ciliary membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt A2A259
TrEMBL
UniProt Splice Variant
Entrez Gene 329064
UniGene Mm.308481
RefSeq NM_181422 XM_006527141 XM_006527142 XM_006527143
OMIM
CCDS CCDS29846
HPRD
IMGT
MGI ID MGI:1352448
MGI Symbol Pkd2l1
EMBL AB290927 AC125101 AF271381 BC116297 BC116323
GenPept AAI16298 AAI16324 AAK58371 BAF45380
RNA Seq Atlas 329064