InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gla

Summary

InnateDB Gene

IDBG-171557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gla

Gene Name

galactosidase, alpha

Synonyms

Ags

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031266

Encoded Proteins

IDBP-171559

galactosidase, alpha

IDBP-537595

galactosidase, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102393:
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:134588149-134601125

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033621	ENSMUSP00000033621
ENSMUST00000153024	ENSMUSP00000123098

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004557	alpha-galactosidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016936	galactoside binding
GO:0042803	protein homodimerization activity
GO:0052692	raffinose alpha-galactosidase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0009311	oligosaccharide metabolic process
GO:0016139	glycoside catabolic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0046477	glycosylceramide catabolic process
GO:0051001	negative regulation of nitric-oxide synthase activity