Bos taurus Gene: MBD3 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-645666.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | MBD3 | ||||||||||||||||
Gene Name | methyl-CpG-binding domain protein 3 | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000038409 | ||||||||||||||||
Encoded Proteins |
methyl-CpG-binding domain protein 3
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071655:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 7:45577377-45579729 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME |
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I Promoter Clearance pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Gene Expression pathway
HDACs deacetylate histones pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Transcription Initiation pathway
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KEGG | |||||||||||||||||
INOH | |||||||||||||||||
PID NCI |
Signaling events mediated by HDAC Class I
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | F1MCI5 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 616090 | ||||||||||||||||
UniGene | Bt.5866 | ||||||||||||||||
RefSeq | NM_001128505 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02020270 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 616090 | ||||||||||||||||