InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MBD3

Summary

InnateDB Gene

IDBG-645666.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBD3

Gene Name

methyl-CpG-binding domain protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000038409

Encoded Proteins

IDBP-698394

methyl-CpG-binding domain protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071655:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45577377-45579729

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003926

ENSBTAP00000003926

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006346	methylation-dependent chromatin silencing
GO:0009888	tissue development
GO:0016573	histone acetylation
GO:0043044	ATP-dependent chromatin remodeling

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016581	NuRD complex
GO:0043234	protein complex