InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bnip3l

Summary

InnateDB Gene

IDBG-175760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bnip3l

Gene Name

BCL2/adenovirus E1B interacting protein 3-like

Synonyms

C86132; D14Ertd719e; Nip3L; Nix

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022051

Encoded Proteins

IDBP-175762

BCL2/adenovirus E1B interacting protein 3-like

IDBP-258811

BCL2/adenovirus E1B interacting protein 3-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26253785

Mitophagy-inducing proteins Bnip3 and Bnip3l play a regulatory role in the generation of robust natural killer cell memory.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104765:
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:66985239-67008877

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022634	ENSMUSP00000022634
ENSMUST00000111115	ENSMUSP00000106744
ENSMUST00000138160
ENSMUST00000151059
ENSMUST00000142593
ENSMUST00000135703
ENSMUST00000129605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005521	lamin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0035694	mitochondrial protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043069	negative regulation of programmed cell death
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0097345	mitochondrial outer membrane permeabilization

Cellular Component

GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000104765

View Gene Order

ENSBTAG00000021307

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

Q9Z2F7

TrEMBL

UniProt Splice Variant

Entrez Gene

12177

UniGene

Mm.29820 Mm.347081 Mm.397984 Mm.407225 Mm.427119

RefSeq

NM_009761 XM_006515292 XM_006518471 XM_006542945

OMIM

CCDS

CCDS27227

HPRD

IMGT

MGI ID

MGI:1332659

MGI Symbol

Bnip3l

EMBL

AF067395 AK004667 AK007920 AK013467 AK018668 AK139950 AK155040 BC085237

GenPept

AAD03588 AAH85237 BAB23456 BAB25351 BAB28869 BAB31334 BAE24194 BAE33007

RNA Seq Atlas

100043324 102641641 12177