InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIP5K1C

Summary

InnateDB Gene

IDBG-17648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIP5K1C

Gene Name

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

Synonyms

LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5Kgamma

Species

Homo sapiens

Ensembl Gene

ENSG00000186111

Encoded Proteins

IDBP-17650

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

IDBP-596801

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

IDBP-603764

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

IDBP-764988

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3630183-3700479

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000335312	ENSP00000335333
ENST00000539785	ENSP00000445992
ENST00000537021	ENSP00000444779
ENST00000592530
ENST00000587482
ENST00000589578	ENSP00000466363

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:1990147	talin binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006909	phagocytosis
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0016079	synaptic vesicle exocytosis
GO:0016337	single organismal cell-cell adhesion
GO:0030036	actin cytoskeleton organization
GO:0030593	neutrophil chemotaxis
GO:0034333	adherens junction assembly
GO:0044281	small molecule metabolic process
GO:0046488	phosphatidylinositol metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0048488	synaptic vesicle endocytosis
GO:0070527	platelet aggregation
GO:0072583	clathrin-mediated endocytosis

Cellular Component

GO:0001891	phagocytic cup
GO:0001931	uropod
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0012505	endomembrane system
GO:0032587	ruffle membrane