Mus musculus Gene: Marveld2
Summary
InnateDB Gene IDBG-178158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Marveld2
Gene Name MARVEL (membrane-associating) domain containing 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021636
Encoded Proteins
MARVEL (membrane-associating) domain containing 2
MARVEL (membrane-associating) domain containing 2
MARVEL (membrane-associating) domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152939:
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:100595957-100616971
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000022137 ENSMUSP00000022137
ENSMUST00000163163 ENSMUSP00000129990
ENSMUST00000168772 ENSMUSP00000126438
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007605 sensory perception of sound
GO:0045216 cell-cell junction organization
GO:0061028 establishment of endothelial barrier
GO:0070830 tight junction assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0033010 paranodal junction
GO:0043220 Schmidt-Lanterman incisure
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q3UZP0
TrEMBL A1BQX3 A1BQX4 A1BQX5 A3KML9
UniProt Splice Variant
Entrez Gene 218518
UniGene Mm.25300 Mm.401839
RefSeq NM_001038602 NM_178410 XM_006517605
OMIM
CCDS CCDS26732 CCDS49345
HPRD
IMGT
MGI ID MGI:2446166
MGI Symbol Marveld2
EMBL AB219935 AK133741 BC003296 BC049919 BC132330 BC132356 DQ143929 DQ682659 DQ682660 DQ682661
GenPept AAH03296 AAH49919 AAI32331 AAI32357 ABA18656 ABG89107 ABG89108 ABG89109 BAE21816 BAE54512
RNA Seq Atlas 218518