Homo sapiens Gene: SERPIND1
Summary
InnateDB Gene IDBG-1808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPIND1
Gene Name serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Synonyms D22S673; HC2; HCF2; HCII; HLS2; LS2; THPH10;
Species Homo sapiens
Ensembl Gene ENSG00000099937
Encoded Proteins
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20773879-20787720
Strand Forward strand
Band q11.21
Transcripts
ENST00000215727 ENSP00000215727
ENST00000406799 ENSP00000384050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0006935 chemotaxis
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Formation of Fibrin Clot (Clotting Cascade) pathway
Intrinsic Pathway pathway
Common Pathway pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P05546
TrEMBL
UniProt Splice Variant
Entrez Gene 3053
UniGene Hs.474270
RefSeq NM_000185 XM_005261597
HUGO HGNC:4838
OMIM 142360
CCDS CCDS13783
HPRD 00795
IMGT
EMBL AK314200 CH471176 CR456573 M12849 M33660 M58600 X03498
GenPept AAA36185 AAA52641 AAA52642 BAG36878 CAA27218 CAG30459 EAX02941 EAX02942
RNA Seq Atlas 3053