InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CXCL12

Summary

InnateDB Gene

IDBG-632037.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL12

Gene Name

stromal cell-derived factor 1 precursor

Synonyms

SDF1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005077

Encoded Proteins

IDBP-683620

stromal cell-derived factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24000293

[Homo sapiens] MIR141 directly regulates CXCL12 expression and CXCL12 mediated leukocyte migration during colonic inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107562:
This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:45410676-45418793

Strand

Forward strand

Band

Transcripts

ENSBTAT00000031279

ENSBTAP00000031235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0042379	chemokine receptor binding
GO:0045236	CXCR chemokine receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001667	ameboidal cell migration
GO:0006955	immune response
GO:0007281	germ cell development
GO:0007420	brain development
GO:0008045	motor neuron axon guidance
GO:0008354	germ cell migration
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0042098	T cell proliferation
GO:0045785	positive regulation of cell adhesion
GO:0050930	induction of positive chemotaxis
GO:0060326	cell chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000406	positive regulation of T cell migration