InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Racgap1

Summary

InnateDB Gene

IDBG-183510.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Racgap1

Gene Name

Rac GTPase-activating protein 1

Synonyms

AI227039; AI327394; Band25; gtl11; GTPase; MgcRacGAP; mKIAA1478

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023015

Encoded Proteins

IDBP-183512

Rac GTPase-activating protein 1

IDBP-262091

Rac GTPase-activating protein 1

IDBP-624676

Rac GTPase-activating protein 1

IDBP-624680

Rac GTPase-activating protein 1

IDBP-624683

Rac GTPase-activating protein 1

IDBP-624685

Rac GTPase-activating protein 1

IDBP-624687

Rac GTPase-activating protein 1

IDBP-624688

Rac GTPase-activating protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161800:
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:99620496-99651656

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023756	ENSMUSP00000023756
ENSMUST00000109581	ENSMUSP00000105209
ENSMUST00000171702	ENSMUSP00000126417
ENSMUST00000165745
ENSMUST00000169700
ENSMUST00000170369
ENSMUST00000168065	ENSMUSP00000132732
ENSMUST00000171017
ENSMUST00000169810	ENSMUSP00000130876
ENSMUST00000168976
ENSMUST00000165730	ENSMUSP00000130282
ENSMUST00000164983	ENSMUSP00000132471
ENSMUST00000168834
ENSMUST00000171908	ENSMUSP00000128892

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0043014	alpha-tubulin binding
GO:0043015	gamma-tubulin binding
GO:0046872	metal ion binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0000915	cytokinesis, actomyosin contractile ring assembly
GO:0007108	cytokinesis, initiation of separation
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007405	neuroblast proliferation
GO:0008272	sulfate transport
GO:0009790	embryo development
GO:0032467	positive regulation of cytokinesis
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051256	spindle midzone assembly involved in mitosis
GO:0051988	regulation of attachment of spindle microtubules to kinetochore

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0030496	midbody
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032154	cleavage furrow
GO:0051233	spindle midzone
GO:0070062	extracellular vesicular exosome
GO:0072686	mitotic spindle
GO:0097149	centralspindlin complex