Version 5.4
Bos taurus Gene: ARHGAP6
Summary
InnateDB Gene IDBG-639034.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP6
Gene Name rho GTPase-activating protein 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002626
Encoded Proteins
IDBP-691151
Rho GTPase activating protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047648:
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:137588934-137693777
Strand Forward strand
Band
Transcripts
ENSBTAT00000003400 ENSBTAP00000003400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0016004 phospholipase activator activity
GO:0043274 phospholipase binding
Biological Process
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0010518 positive regulation of phospholipase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0048041 focal adhesion assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0051895 negative regulation of focal adhesion assembly
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000047648
View Gene Order
ENSMUSG00000031355
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL F1N6V1
UniProt Splice Variant
Entrez Gene 100140016
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02075018
GenPept
RNA Seq Atlas 100140016

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca