Mus musculus Gene: Atp6v0d1
Summary
InnateDB Gene IDBG-187917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp6v0d1
Gene Name ATPase, H+ transporting, lysosomal V0 subunit D1
Synonyms Ac39; AI267038; Atp6d; P39; VATX; Vma6;
Species Mus musculus
Ensembl Gene ENSMUSG00000013160
Encoded Proteins
ATPase, H+ transporting, lysosomal V0 subunit D1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159720:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c\'\', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105524465-105566047
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000013304 ENSMUSP00000013304
ENSMUST00000144486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0032403 protein complex binding
Biological Process
GO:0007420 brain development
GO:0015991 ATP hydrolysis coupled proton transport
GO:0042384 cilium assembly
Cellular Component
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005813 centrosome
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0043679 axon terminus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Insulin receptor pathway
Unfolded Protein Response (UPR) pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Metabolism of proteins pathway
Iron uptake and transport pathway
IRE1alpha activates chaperones pathway
Transmembrane transport of small molecules pathway
XBP1(S) activates chaperone genes pathway
Insulin receptor recycling pathway
Signal Transduction pathway
KEGG
Oxidative phosphorylation pathway
Lysosome pathway
Phagosome pathway
Collecting duct acid secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Iron uptake and transport pathway
XBP1(S) activates chaperone genes pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Metabolism of proteins pathway
Signaling by Insulin receptor pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Signal Transduction pathway
Signaling by Insulin receptor pathway
IRE1alpha activates chaperones pathway
Metabolism of proteins pathway
XBP1(S) activates chaperone genes pathway
Unfolded Protein Response (UPR) pathway
Insulin receptor recycling pathway
Disease pathway
KEGG
Oxidative phosphorylation pathway
Lysosome pathway
Phagosome pathway
Collecting duct acid secretion pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.17708 Mm.462635
RefSeq NM_013477
OMIM
CCDS CCDS22604
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas