Mus musculus Gene: Pfdn5
Summary
InnateDB Gene IDBG-188389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfdn5
Gene Name prefoldin 5
Synonyms 1190001O17Rik; 1700010A06Rik; D15Ertd697e; Eig1; MM-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000001289
Encoded Proteins
prefoldin 5
prefoldin 5
prefoldin 5
prefoldin 5
prefoldin 5
prefoldin 5
prefoldin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123349:
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102326116-102331873
Strand Forward strand
Band F3
Transcripts
ENSMUST00000001335 ENSMUSP00000001335
ENSMUST00000062492 ENSMUSP00000126970
ENSMUST00000166658 ENSMUSP00000129178
ENSMUST00000168805
ENSMUST00000170627 ENSMUSP00000131245
ENSMUST00000169637 ENSMUSP00000128263
ENSMUST00000165671 ENSMUSP00000128526
ENSMUST00000165717 ENSMUSP00000132441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060041 retina development in camera-type eye
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016272 prefoldin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Protein folding pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Protein folding pathway
KEGG
INOH
PID BIOCARTA
PID NCI
p73 transcription factor network
Cross-References
SwissProt
TrEMBL E9Q093 E9Q5Q8
UniProt Splice Variant
Entrez Gene 56612
UniGene Mm.305461
RefSeq NM_027044
OMIM
CCDS CCDS37227
HPRD
IMGT
MGI ID MGI:1928753
MGI Symbol Pfdn5
EMBL AC163291
GenPept
RNA Seq Atlas 56612