Mus musculus Gene: Alkbh2
Summary
InnateDB Gene IDBG-192205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Alkbh2
Gene Name alkB, alkylation repair homolog 2 (E. coli)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000044339
Encoded Proteins
alkB, alkylation repair homolog 2 (E. coli)
alkB, alkylation repair homolog 2 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189046:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:114123926-114128218
Strand Reverse strand
Band F
Transcripts
ENSMUST00000053657 ENSMUSP00000056043
ENSMUST00000112279 ENSMUSP00000107898
ENSMUST00000149418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734 DNA-N1-methyladenine dioxygenase activity
GO:0051747 cytosine C-5 DNA demethylase activity
Biological Process
GO:0006307 DNA dealkylation involved in DNA repair
GO:0035511 oxidative DNA demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Reversal of Alkylation Damage By DNA Dioxygenases pathway
ABH2 mediated Reversal of Alkylation Damage pathway
DNA Repair pathway
DNA Damage Reversal pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
ABH2 mediated Reversal of Alkylation Damage pathway
Reversal of Alkylation Damage By DNA Dioxygenases pathway
DNA Damage Reversal pathway
DNA Repair pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6P6J4
TrEMBL
UniProt Splice Variant
Entrez Gene 231642
UniGene Mm.332593
RefSeq NM_175016 XM_006530289 XM_006530290 XM_006530292
OMIM
CCDS CCDS19559
HPRD
IMGT
MGI ID MGI:2141032
MGI Symbol Alkbh2
EMBL AK079195 BC062188
GenPept AAH62188 BAC37576
RNA Seq Atlas 231642